Publications — Living System Design Lab

2025

Science

Co-corresponding

Design of high-specificity binders for peptide–MHC-I complexes

Liu, B.*^#, Greenwood, N.F.*, Bonzanini, J.E.*, Motmaen, A., Meyerberg, J., Dao, T., … & Baker, D.^#

Science, 389(6758), 386–391.

2024

Cell Systems

Co-first

Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

Gentili, M.*, Carlson, R.J.*, Liu, B.*, Hellier, Q., Andrews, J., Qin, Y., Blainey, P.C. & Hacohen, N.

Cell Systems, 15(12), 1264–1277.

2023

Science

Co-corresponding

Human STING is a proton channel

Liu, B.*^#, Carlson, R.J.*, Pires, I.S., Gentili, M., Feng, E., Hellier, Q., Schwartz, M.A., Blainey, P.C., Irvine, D.J.^# & Hacohen, N.^#

Science, 381(6657), 508–514.

Nature Comms

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

Gentili, M., Liu, B., Papanastasiou, M., Dele-Oni, D., Schwartz, M.A., Carlson, R.J., Al'Khafaji, A.M., Krug, K., Brown, A., Doench, J.G. & Carr, S.A.

Nature Communications, 14(1), 611.

Nature Immunol.

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Dolan, M.J., Therrien, M., Jereb, S., Kamath, T., Gazestani, V., Atkeson, T., Marsh, S.E., Goeva, A., Lojek, N.M., Murphy, S., White, C.M., … Liu, B., …

Nature Immunology.

2020

bioRxiv

Preprint · First

An efficient lentiviral CRISPRi approach to silence genes in primary human monocytes

Liu, B., Gentili, M., Lieb, D., Eisenhaure, T., Irvine, D.J. & Hacohen, N.

bioRxiv, 2020-12.

2017

Cell

Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras

Wang, T., Yu, H., Hughes, N.W., Liu, B., Kendirli, A., Klein, K., Chen, W.W., Lander, E.S. & Sabatini, D.M.

Cell, 168(5), 890–903.

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